Effects of Prophylactic Human Papilloma Virus (HPV) Vaccine on Oral HPV Infections

Effects of HPV Vaccine on Oral Human Papilloma Virus (HPV) Infections

İnsan Papilloma Virüsü (HPV) Aşısının Oral HPV Enfeksiyonları Üzerindeki Etkisi - Ağızda HPV Enfeksiyonu İçin Aşı - Ağızda Papillom İçin Aşı - HPV İlişkili Oral Kanser SıklığıThe prevalence of HPV positive oropharyngeal cancers has increased in recent years among US men. The potential impact of HPV vaccines on oral HPV infections, efficacy-trials or surveillance (systematic collection, processing and rapid feedback of these assessments to those who will act according to the results obtained, and the process of ensuring rapid feedback of these assessments - source: HPV-associated oropharyngeal cancer: epidemiology ... - Nature).

In a comprehensive study published in the Journal of Clinical Oncology in 2018 and on young adults (18-33 years) in the US between 2011 and 2014, HPV vaccine was found to reduce the frequency of vaccine-induced oral HPV infection. However, due to the low vaccine intake, the activity at the population level is generally low and especially low in males. In other words, HPV vaccination for protective purposes without signs of infection may reduce the contents of the throat and mouth region, although not all of the Human Papilloma Virus (HPV) infections (study link >> Effect of Prophylactic Human Papillomavirus (HPV) Vaccination on Oral HPV Infections Among Young Adults in the United States). The incidence of human papillomavirus (HPV) - positive oropharyngeal cancers has increased rapidly among men in the US in recent years.

The incidence of HPV - positive oropharyngeal cancers is increasing!

The incidence of oropharyngeal cancer caused by human papilloma virus (HPV) infection has increased rapidly in men in the US and in numerous other developed countries around the world. In addition, HPV-positive oropharyngeal cancer is expected to be the most common among HPV positive cancers. More than 70% of approximately 12,000 oropharyngeal cancers diagnosed each year in the United States are caused by HPV. Approximately 90% of HPV positive oropharyngeal cancers caused by HPVTip 16 are cancers and other oncogenic HPV types. Given the absence of screening and secondary protection strategies, the prophylactic HPV vaccine has the greatest potential for preventing HPV-positive oropharyngeal cancers. The efficacy of over 90% vaccination in the prevention of anogenital HPV infections and precancerous lesions in different clinical trials has been demonstrated. Again, the prevalence of genital HPV in young American women also shows a significant reduction in population level after vaccination. Unfortunately, few studies assess the effect of HPV vaccine on population HPV infections.

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Difficulties in assessing the effect of vaccine in oral HPV infections

In oral HPV infections, it is not easy to detect the presence of HPV virus in the mouth and determine the effectiveness of the vaccine in an individual due to reasons such as the fact that the findings cannot always be easily detected, the virus can be found in the mouth without leyon, the HPV virus does not always cause the lesion. Considering the rapid increase in the incidence of oropharyngeal cancers in recent years, especially in men in the United States and in a number of other developed countries, including Australia, Canada, Denmark, Japan and Sweden, the reduction of oral HPV infections by vaccination may be of high importance for global public health .

Other sources >>

  • Human papillomavirus and rising oropharyngeal cancer incidence in ...
  • CDC - Assessment of HPV Types in Cancers
  • Epidemiology of human papillomavirus-positive head and neck ...
  • Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated - CDC
  • Primary End-points for Prophylactic HPV Vaccine Trials, IARC Working
  • Prevalence of HPV After Introduction of the Vaccination Program in the ...

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