Ototoxicity and Ototoxic Drugs
Drug Induced Hearing Loss
|Ototoxicity - Ototoxic drugs - Internal ear damaging drugs - Tinnitus - A list of ototoxic drugs - Sensorineural hearing loss - Hair cells (HCs) damage in inner ear - List of ototoxic medications - Drug induced hearing loss / Image source: The 5 Different types of hearing loss ...|
Drug ototoxicity, especially in psychosocial problems, limits the quality of life of patients after treatment, those with serious consequences. The use of platinum derivatives and aminoglycosides is associated with permanent loss of hearing, although many medications have improved after discontinuation of treatment. In the literature, a number of compounds have been identified as ototoxic. The degree or incidence of ototoxicity can vary widely between drugs, and sometimes a drug can be listed as possible ototoxic if only one ototoxicity is suspected. Even among agents known to be ototoxic, the incidence of ototoxic hearing loss may be so low that official ototoxicity monitoring may not be recommended.
In particular, patients who have previously experienced a problem with the inner ear, who have tinnitus (with neural type - sensorineural hearing loss), should avoid these medications as much as possible.
Sensorineural hearing loss (SNHL)Sensorineural hearing loss (SNHL) is a common sensory deficiency characterized by tissue damage and / or cell death in the cochlea. Moderate and severe SNHL cause deficiencies in communication, cause more isolation than human relations and negatively affect employability. Many etiology are associated with SNHL: Noise over-exposure, some drugs, internal or middle ear infection, or immune-induced inflammation are common. However, the most common form of SNHL is presbycusis or age-related hearing loss, often exacerbated by other factors such as noise exposure, diabetes, or high blood pressure. Although systemic steroids have been used in the treatment of sudden SNHL, other drugs have not yet been developed to prevent or treat hearing loss. The cochlear sensory cells known as cochlear hair cells (HCs) and neurons have a very limited repair capacity. Moreover, since these cells are not regenerated, any loss is permanent and therefore the prevention of cell damage is critical in maintaining the hearing (sources >> Screening antioxidants for the protection of cochlear sensory cells / The role of oxidative stress in noise-induced hearing loss).
Drugs that damage the inner ear can be classified as "harmful" and "potentially harmful". This drug can also be listed as drugs that can cause tinnitus.
Reactive oxygen species (ROS) contribute to hair cell damage
|Ototoxicity - Ototoxic drugs - Internal ear damaging drugs - Tinnitus - A list of ototoxic drugs - Sensorineural hearing loss - Hair cells (HCs) damage in inner ear - List of ototoxic medications - Drug induced hearing loss / Image source: Hearing aids, cochlear implants and hearing|
Can ototoxicity be prevented by using antioxidant drugs?
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